Cryobanks and automation systems

SYNTHESY designs and installs modular systems worldwide that ensure the automatic management of cryobanks and related equipment. Constant monitoring of operational parameters is a key point for the success of cryopreservation of biological samples. SINTESY has developed innovative solutions to ensure the protection of operators, stored samples and acquired digital data.

Cryobanks

Cryopreservation of cells, tissues, DNA, RNA, blood, embryos and other biomolecules is of fundamental importance for scientific and medical research, for the development of new therapies and for the preservation of biological diversity. Biological samples are invaluable in many scientific and medical fields and their loss would have serious consequences in research, legal, ethical and economic fields. Therefore, it is crucial that organisations that manage cryobanks take strict measures to ensure safe long-term preservation.

Switchover

Cryogenic tank switchover is a system used to ensure a continuous flow of gases or liquids without interruption by automatically switching from a depleted tank to a full one. This system is particularly useful in medical, research and industrial applications where continuity of flow is critical. The advantages of such use are operational continuity, safety, efficiency and reliability.

Controller for phase separator

Phase separators for cryogenic applications are devices for handling fluids at extremely low temperatures, such as liquefied gases, e.g. liquid nitrogen. They are designed to separate liquid and gas phases, ensuring that only the liquid phase is used for cryogenic filling processes.

LN2 cryogenic line automation

Super-insulated vacuum cryogenic lines (SIVL) are used to fill cryo containers with liquid nitrogen. The filling process requires a preliminary 'cold-start' phase, which prevents nitrogen in a gaseous state from being introduced into the cryogenic equipment used to store biological samples, causing an undesirable rise in temperature.

Automatic Pressurised Filling

The filling process of pressurised tanks containing liquid nitrogen requires a specific sequence of opening and closing the nitrogen inlet valve and venting valve. This process requires the management of the tank's internal pressure and the detection of the internal liquid quantity that triggers the filling process. The automation of this process helps to protect the safety of operators.

AREAS OF APPLICATION

Cryobank automation systems are used in various sectors for storing biological samples in liquid nitrogen at -196°C. Some of the application areas are:

  • cryopreservation
  • research and biotechnology, for the preservation of stem cells, tissues and organs, for medically assisted reproduction and for the preservation of gametes and embryos
  • the pharmaceutical chemicals sector, for the preservation of strains of bacteria and viruses or production of biomaterials

Research and biotechnology

Life science

Cryopreservation

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